The Secret Life of Histones

نویسندگان

  • David A.F Gillespie
  • Karen H Vousden
چکیده

Recent evidence reveals an unexpected role for the linker histone H1.2 in DNA damage-induced apoptosis. DNA double strand breaks induce translocation of nuclear H1.2 to the cytoplasm, where it promotes release of cytochrome c from mitochondria by activating the Bcl-2 family protein, Bak.

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عنوان ژورنال:
  • Cell

دوره 114  شماره 

صفحات  -

تاریخ انتشار 2003